Kinasera offers to biotech and pharmaceutical companies and academic laboratories
novel tools for research targeted to protein kinases and their inhibitors.
Development
Kinasera holds exclusive licenses for affinity carriers and fluorescent probes originating from novel bisubstrate-type
protein kinase inhibitors with high affinity (Kd = 0.01 ... 3 nM) towards basophilic kinases. These inhibitors are used for
elaboration of biosensors and fluorescent probes for protein kinase research and inhibitor screening, and drug development.
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ARC-Photo is an assay kit for characterization of binding of inhibitors to protein kinases. The kit
can be used for HTS of inhibitors in 384- or 1536-well microtiter plate format with fluorescence polarization (anisotropy) detection.
Resulting from bisubstrate character of ARC-type inhibitors ARC-Photo can be used for characterization of inhibitors targeted to both
ATP- and protein/peptide-competitive inhibitors of kinases.
ARC-Photo differs from most of other available protein kinase inhibitor screening technologies as it measures the binding of the inhibitor
to the kinase instead of determination of the retarding effect of the inhibitor on phosphorylation reaction. That makes the assay simpler, quicker, and cheaper.
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